pliva 433

pliva 433

PLIVA 433, also known as Trazodone Hydrochloride 50 mg, is a pill used to treat insomnia, depression, anxiety, fibromyalgia and more. The drug belongs to the class phenylpiperazine antidepressants. Trazodone can help improve your appetite, mood and energy levels.

At the same time, taking this pill is said to decrease insomnia and anxiety related to depression. This is because trazodone helps in restoring the balance of the natural chemical in the brain, the serotonin.

Dosage and Administration of Trazodone

The dosage for taking trazodone has to be started at a low dose, which is gradually increased while noting the medical response to the medicine administrated. Any signs of intolerance of the medicine should be noted as well.

If there is an incidence of drowsiness, it may indicate that there is a need to administer a major percentage of the everyday dose at time for bed or it may also mean the need to reduce the dosage. Trazodone must be taken after a mealtime or a light snack.

The initial dose when taking trazodone is 150 mg per day. The dose should be taken in divided dose and then amplified by 50 mg/day within every 3 to 4 days. For outpatients, the maximum dosage must not exceed to 400 mg/day and in allocated doses.

On the other hand, for inpatients, which are the most depressed patients, must not be given more than 600 mg/day in divided dose. When adequate response can be seen, the dosage can be progressively reduced.

Warning and Precautions

When taking trazodone, patients who have major depressive disorder might experience getting worse of their depression. Similarly, there may be a development of morbid ideation and unusual changes in their behavior.

This risk may persist until a remission occurs. Suicide is known risk of depression and with that, such patients with major depression must be monitored regularly as there is risk that taking antidepressants like trazodone or PLIVA 433 can worsen their condition.

Maintenance Treatment

Trazodone’s efficacy for maintenance treatment for major depressive disorder has not yet been evaluated. There is yet any evidence that can answer how long does a patient treated with trazodone hydrochloride tablets must continue the drug.

But it is generally recommended that the treatment is continued for a few months after the occurrence of initial response. But patients should be maintained in the lowest effective dosage while being periodically reassessed in order to determine if there is a need for continued maintenance treatment of PLIVA 433.


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